Cell adhesion molecule L1 contributes to neuronal excitability regulating the function of voltage-gated sodium channels
نویسندگان
چکیده
* present address: Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London WC1N 3BG, UK § present address: Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY, USA ^ present address: Department of Pharmacy, University of Napoli Federico II, Napoli, Italy ° present address: Cognitive Neuroscience, Sensorimotor Laboratory, German Primate Center, Leibniz Institute for Primate Research, Gottingen, Germany
منابع مشابه
Cell adhesion molecule L1 contributes to neuronal excitability regulating the function of voltage-gated Na+ channels.
L1 (also known as L1CAM) is a trans-membrane glycoprotein mediating neuron-neuron adhesion through homophilic and heterophilic interactions. Although experimental evidence has implicated L1 in axonal outgrowth, fasciculation and pathfinding, its contribution to voltage-gated Na(+) channel function and membrane excitability has remained unknown. Here, we show that firing rate, single cell spikin...
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